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Long-acting depot antipsychoticswhich have myelosuppressive potentialmust not be used concurrently with Clozaril because these cannot be rapidly removed from the body in situations where this may be requirede.gneutropeniasee section 4.3

Clozapine can cause low blood pressure or a slow heartbeatwhich can make you dizzy or cause you to faint when you stand upThe risk is higher when you first start or increase your dose of medicationDizziness and lightheadedness can increase the risk of fallingGet up slowly when rising from a sitting or lying position.

Clozaril can cause agranulocytosisThe incidence of agranulocytosis and the fatality rate in those developing agranulocytosis have decreased markedly since the institution of white blood cellWBCcounts and absolute neutrophil countANCmonitoringThe following precautionary measures are therefore mandatory and should be carried out in accordance with official recommendations.

Tell your doctor if you are a descendent of Ashkenazi Jews because you may be at a higher risk for a drop in your white blood cells.

The Clozaril Patient Monitoring Service provides for the centralised monitoring of leucocyte and neutrophil counts which is a mandatory requirement for all patients in the UK who are treated with ClozarilThe use of Clozaril is restricted to patients who are registered with the Clozaril Patient Monitoring ServiceIn addition to registering their patientsprescribing physicians must register themselves and a nominated pharmacist with the Clozaril Patient Monitoring ServiceAll Clozaril-treated patients must be under the supervision of an appropriate specialist and supply of Clozaril is restricted to hospital and retail pharmacies registered with the Clozaril Patient Monitoring ServiceClozaril is not sold toor distributed through wholesalers.

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