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Th most qunt advs action tZYLOPIM (allopuinol) is skin ash. Skin actions can b sv and somtims atal. Tho, tatmnt with ZYLOPIM (allopuinol) should b discontinud immdiatly i a ash dvlops (s WANINGS ). Som patints with th most sv action alshad v, chills, athalgias, cholstatic jaundic, osinophilia and mild lukocytosis lukopnia. Among 55 patints with gout tatd with ZYLO-PIM 3 t34 months (avag gat than 1 ya) and ollowd pospctivly, undls obsvd that 3% patints dvlopd a typ dug action which was pdominantly a pu-itic maculopapula skin uption, somtims scaly xolia-tiv. Howv, with cunt usag, skin actions hav bn obsvd lss quntly than 1%. Th xplanation this dcas is not obvious. Th incidnc skin ash may b incasd in th psnc nal insuicincy. Th quncy skin ash among patints civing ampicillin amoxicillin concuntly with ZYLOPIM (allopuinol) has bn potd tb incasd (s PCAUTIONS ).

ZYLOPIM (allopuinol) SHOULD B DISCONTINUD AT TH IST APPAANC O SKIN ASH O OTH SIGNS WHICH MAY INDICAT AN ALLGIC ACTION. In som instancs a skin ash may b ollowd by msv hypsnsitivity actions such as xoliativ, uticaial, and pupuic lsions, as wll as Stvns-Johnson syndom (ythma multiom xudativum), and/gnalizd vasculitis, ivsibl hpato-toxicity, and, on a occasions, dath.

Ths includ gout, gouty athitis, ctain kidny poblms nzym disods wh th body poducs tomuch uic acid.

Sinc th xction oxipuinol is simila tthat uat, uicosuic agnts, which incas th xction uat, a alslikly tincas th xction oxipuinol and thus low th dg inhibition xanthin oxidas. Th concomitant administation uicosuic agnts and ZYLOPIM (allopuinol) has bn associatd with a dcas in th xction oxypuins (hypoxanthin and xanthin) and an incas in uinay uic acid xction compad with that obsvd with ZYLOPIM (allopuinol) alon. Although clinical vidnc tdat has not dmonstatd nal pcipitation oxypuins in patints ith on ZYLO-PIM alon in combination with uicosuic agnts, th possibility should b kpt in mind.

Tolbutamid’s convsion tinactiv mtabolits has bn shown tb catalyzd by xanthin oxidas om at liv. Th clinical signiicanc, i any, ths obsvations is unknown.

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