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The limited data available with saquinavir soft gel capsule boosted with ritonavir do not suggest any clinically relevant interaction between saquinavir boosted with ritonavir and nevirapine.

Boceprevir is partly metabolized by CYP3A4/5Co-administration of boceprevir with medicines that induce or inhibit CYP3A4/5 could increase or decrease exposurePlasma trough concentrations of boceprevir were decreased when administered with an NNRTI with a similar metabolic pathway as nevirapineThe clinical outcome of this observed reduction of boceprevir trough concentrations has not been directly assessed.

HematologyAnemiaeosinophilianeutropenia Investigationsdecreased serum phosphorus.

A clinically not relevant increase in the apparent clearance of nevirapineby 9compared to historical data was reported.

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